"Anti-HBe assay is used to perform qualitative detection of antibody to hepatitis B e antigen in human serum and plasma. During recovery from acute hepatitis B, the hepatitis B e-antigen (HBeAg) level declines and becomes undetectable and hepatitis B e-antibody (anti-HBe) appears in the serum. Anti-HBe usually remains detectable for several years after recovery from acute infection.
In hepatitis B virus (HBV) carriers and in patients with chronic hepatitis B, positive anti-HBe results usually indicate inactivity of the virus and low infectivity of the patients. Positive anti-HBe results in the presence of detectable HBV DNA in serum indicate active viral replication.